Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES

Martin J. Pfeiffer; Roberto Quaranta; Ilaria Piccini; Jakob Fell; Jyoti Rao; Albrecht Röpke; Guiscard Seebohm; Boris Greber

doi:10.1038/s41467-017-02812-6

Nature Communications (Jan 2018)

Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES

Martin J. Pfeiffer,
Roberto Quaranta,
Ilaria Piccini,
Jakob Fell,
Jyoti Rao,
Albrecht Röpke,
Guiscard Seebohm,
Boris Greber

Affiliations

Martin J. Pfeiffer: Human Stem Cell Pluripotency Laboratory, Max Planck Institute for Molecular Biomedicine
Roberto Quaranta: Human Stem Cell Pluripotency Laboratory, Max Planck Institute for Molecular Biomedicine
Ilaria Piccini: Human Stem Cell Pluripotency Laboratory, Max Planck Institute for Molecular Biomedicine
Jakob Fell: Human Stem Cell Pluripotency Laboratory, Max Planck Institute for Molecular Biomedicine
Jyoti Rao: Human Stem Cell Pluripotency Laboratory, Max Planck Institute for Molecular Biomedicine
Albrecht Röpke: Institute of Human Genetics, University Hospital Münster
Guiscard Seebohm: Department of Cardiovascular Medicine, Institute of Genetics of Heart Diseases, University of Münster Medical School
Boris Greber: Human Stem Cell Pluripotency Laboratory, Max Planck Institute for Molecular Biomedicine

DOI: https://doi.org/10.1038/s41467-017-02812-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 8

Abstract

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The T-box transcription factor eomesodermin (EOMES) acts both in endoderm specification as well as heart development, suggesting context-specific function. Here, the authors show that dose-controlled EOMES induction is sufficient for cardiogenic programming of human pluripotent stem cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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