A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

Xiao-Feng Zheng; Sanket S. Acharya; Katherine N. Choe; Kumar Nikhil; Guillaume Adelmant; Shakti Ranjan Satapathy; Samanta Sharma; Keith Viccaro; Sandeep Rana; Amarnath Natarajan; Peter Sicinski; Jarrod A. Marto; Kavita Shah; Dipanjan Chowdhury

doi:10.1038/s41467-019-12084-x

Nature Communications (Sep 2019)

A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

Xiao-Feng Zheng,
Sanket S. Acharya,
Katherine N. Choe,
Kumar Nikhil,
Guillaume Adelmant,
Shakti Ranjan Satapathy,
Samanta Sharma,
Keith Viccaro,
Sandeep Rana,
Amarnath Natarajan,
Peter Sicinski,
Jarrod A. Marto,
Kavita Shah,
Dipanjan Chowdhury

Affiliations

Xiao-Feng Zheng: Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School
Sanket S. Acharya: Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School
Katherine N. Choe: Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School
Kumar Nikhil: Department of Chemistry and Purdue University Center for Cancer Research, Purdue University
Guillaume Adelmant: Department of Cancer Biology, Dana-Farber Cancer Institute
Shakti Ranjan Satapathy: Department of Chemistry and Purdue University Center for Cancer Research, Purdue University
Samanta Sharma: Department of Cancer Biology, Dana-Farber Cancer Institute
Keith Viccaro: Department of Chemistry and Purdue University Center for Cancer Research, Purdue University
Sandeep Rana: Eppley Institute for Research in Cancer, University of Nebraska Medical Center
Amarnath Natarajan: Eppley Institute for Research in Cancer, University of Nebraska Medical Center
Peter Sicinski: Department of Cancer Biology, Dana-Farber Cancer Institute
Jarrod A. Marto: Department of Cancer Biology, Dana-Farber Cancer Institute
Kavita Shah: Department of Chemistry and Purdue University Center for Cancer Research, Purdue University
Dipanjan Chowdhury: Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-019-12084-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

Regulation of post translational modification of 53BP1 is critical for genome integrity and regulation of DNA damage response. Here the authors reveal a CDK5-PP4 phospho-signaling cascade that leads 53BP1 to sites of DNA damage.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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