Clinics (Jan 2010)

Anti-hypertensive drugs have different effects on ventricular hypertrophy regression

  • Celso Ferreira Filho,
  • Luiz Carlos de Abreu,
  • Vitor E. Valenti,
  • Marcelo Ferreira,
  • Adriano Meneghini,
  • José Alexandre Silveira,
  • Andrés R. Pérez Riera,
  • Eduardo Colombari,
  • Neif Murad,
  • Paulo Roberto Santos-Silva,
  • Lovian José Henrique Pereira da Silva,
  • Luiz Carlos Marques Vanderlei,
  • Tatiana D. Carvalho,
  • Celso Ferreira

DOI
https://doi.org/10.1590/S1807-59322010000700012
Journal volume & issue
Vol. 65, no. 7
pp. 723 – 728

Abstract

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OBJECTIVES: There is a direct relationship between the regression of left ventricular hypertrophy (LVH) and a decreased risk of mortality. This investigation aimed to describe the effects of anti-hypertensive drugs on cardiac hypertrophy through a meta-analysis of the literature. METHODS: The Medline (via PubMed), Lilacs and Scielo databases were searched using the subject keywords cardiac hypertrophy, antihypertensive and mortality. We aimed to analyze the effect of anti-hypertensive drugs on ventricle hypertrophy. RESULTS: The main drugs we described were enalapril, verapamil, nifedipine, indapamina, losartan, angiotensin-converting enzyme inhibitors and atenolol. These drugs are usually used in follow up programs, however, the studies we investigated used different protocols. Enalapril (angiotensin-converting enzyme inhibitor) and verapamil (Ca++ channel blocker) caused hypertrophy to regress in LVH rats. The effects of enalapril and nifedipine (Ca++ channel blocker) were similar. Indapamina (diuretic) had a stronger effect than enalapril, and losartan (angiotensin II receptor type 1 (AT1) receptor antagonist) produced better results than atenolol (selective β1 receptor antagonist) with respect to LVH regression. CONCLUSION: The anti-hypertensive drugs induced various degrees of hypertrophic regression.

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