Beyond the method change in clinical practice: evaluation of insulin-like growth factor I assay

Abstract

Insulin-like growth factor I (IGF-I) is the preferred biomarker for diagnosing and monitoring growth-related disorders but its serum quantification presents several difficulties since different IGF-I assays still leads to different IGF-I concentrations, especially when results are either above or below the normal range.

Keywords

• growth hormone
• immunoassay
• insulin-like growth factor i
• method comparison