Association of indicators of arterial rigidity and arrithmogenesis in Novosibirsk men population

Abstract

Pulse wave amplification and augmentation are considered as new indicators of arterial stiffness. It is of interest to study their association with electrocardiographic pro-arrhythmic patterns in the male population of Novosibirsk. Material and methods. We used data from a representative sample of 145 men aged 25-44 years from a population of inhabitants of Novosibirsk. Applanation tonometry of the radial artery and pulse wave analysis were performed using the SphygmoCor system (AtCorMedical, Australia). The Brugada pattern, the pattern of early ventricular repolarization and fragmentation of the QRS complex were determined on a resting electrocardiogram according to generally accepted current criteria. When analyzing the data, descriptive statistics methods and the general linear model (GLM) were used. Results. Fragmentation of the QRS complex in the in the area of the inferior wall of the left ventricle, regardless of age, body mass index and heart rate, was associated with a decrease in the ratio of amplification of pulse pressure (F = 5.34; p = 0.022), amplification of pulse pressure (F = 5.91; p = 0.016) and amplification of systolic pressure (F = 5.02; p = 0.027). Conclusion. In the Novosibirsk male population, a decrease in pulse wave amplification was associated with fragmentation of the QRS complex. The results of this study demonstrate the relevance of an integrated assessment of prognostically significant indicators of arterial stiffness and ventricular pro-arrhythmia to study the possible cumulation of cardiovascular risk.

Keywords

• arterial stiffness
• pulse wave amplification
• pulse wave augmentation
• brugada pattern
• early repolarization
• qrs fragmentation