PLoS ONE (Jan 2024)

Increased serum caspase-1 in adult-onset Still's disease.

  • Haruki Matsumoto,
  • Shuhei Yoshida,
  • Tomohiro Koga,
  • Yuya Fujita,
  • Yuya Sumichika,
  • Kenji Saito,
  • Jumpei Temmoku,
  • Tomoyuki Asano,
  • Shuzo Sato,
  • Masashi Mizokami,
  • Masaya Sugiyama,
  • Kiyoshi Migita

DOI
https://doi.org/10.1371/journal.pone.0307908
Journal volume & issue
Vol. 19, no. 7
p. e0307908

Abstract

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BackgroundCaspase-1 is a crucial component in the inflammasome activation cascade. This study evaluated the potential of serum caspase-1 level as an inflammatory biomarker in patients with adult-onset Still's disease (AOSD).MethodsThe study included 51 consecutive patients diagnosed with AOSD based on the Yamaguchi criteria, 66 patients with rheumatoid arthritis (RA) as disease control, and 36 healthy controls (HCs). Serum caspase-1 concentrations were measured using enzyme-linked immunosorbent assay. The serum 69 cytokine levels were analyzed using a multisuspension cytokine array in patients with AOSD, and a cluster analysis of each cytokine was performed to determine specific molecular networks.ResultsPatients with AOSD had significantly increased serum caspase-1 levels versus patients with RA (p ConclusionsCaspase-1 is a useful biomarker for AOSD diagnosis and monitoring. Caspase-1 activation could be correlated with the inflammatory component of AOSD, specifically through proinflammatory cytokine induction via inflammasome activation cascades.