Biological functions and research progress of eIF4E

Xiaocong Chen; Yang An; Mengsi Tan; Dongrui Xie; Ling Liu; Ling Liu; Ling Liu; Benjin Xu; Benjin Xu; Benjin Xu

doi:10.3389/fonc.2023.1076855

Frontiers in Oncology (Aug 2023)

Biological functions and research progress of eIF4E

Xiaocong Chen,
Yang An,
Mengsi Tan,
Dongrui Xie,
Ling Liu,
Ling Liu,
Ling Liu,
Benjin Xu,
Benjin Xu,
Benjin Xu

Affiliations

Xiaocong Chen: Department of Clinical Medicine, Fenyang College of Shanxi Medical University, Fenyang, China
Yang An: Department of Clinical Medicine, Fenyang College of Shanxi Medical University, Fenyang, China
Mengsi Tan: Department of Clinical Medicine, Fenyang College of Shanxi Medical University, Fenyang, China
Dongrui Xie: Department of Clinical Medicine, Fenyang College of Shanxi Medical University, Fenyang, China
Ling Liu: Department of Medical Laboratory Science, Fenyang College of Shanxi Medical University, Fenyang, China
Ling Liu: Key Laboratory of Lvliang for Clinical Molecular Diagnostics, Fenyang, China
Ling Liu: Department of Clinical Laboratory, Fenyang Hospital of Shanxi Province, Fenyang, China
Benjin Xu: Department of Medical Laboratory Science, Fenyang College of Shanxi Medical University, Fenyang, China
Benjin Xu: Key Laboratory of Lvliang for Clinical Molecular Diagnostics, Fenyang, China
Benjin Xu: Department of Clinical Laboratory, Fenyang Hospital of Shanxi Province, Fenyang, China

DOI: https://doi.org/10.3389/fonc.2023.1076855
Journal volume & issue: Vol. 13

Abstract

Read online

The eukaryotic translation initiation factor eIF4E can specifically bind to the cap structure of an mRNA 5' end, mainly regulating translation initiation and preferentially enhancing the translation of carcinogenesis related mRNAs. The expression of eIF4E is closely related to a variety of malignant tumors. In tumor cells, eIF4E activity is abnormally increased, which stimulates cell growth, metastasis and translation of related proteins. The main factors affecting eIF4E activity include intranuclear regulation, phosphorylation of 4EBPs, and phosphorylation and sumoylation of eIF4E. In this review, we summarize the biological functions and the research progress of eIF4E, the main influencing factors of eIF4E activity, and the recent progress of drugs targeting eIF4E, in the hope of providing new insights for the treatment of multiple malignancies and development of targeted drugs.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

About the journal

Abstract

Keywords