Nature Communications (Apr 2020)
Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas
- Jay Daniels,
- Peter G. Doukas,
- Maria E. Martinez Escala,
- Kimberly G. Ringbloom,
- David J. H. Shih,
- Jingyi Yang,
- Kyle Tegtmeyer,
- Joonhee Park,
- Jane J. Thomas,
- Mehmet E. Selli,
- Can Altunbulakli,
- Ragul Gowthaman,
- Samuel H. Mo,
- Balaji Jothishankar,
- David R. Pease,
- Barbara Pro,
- Farah R. Abdulla,
- Christopher Shea,
- Nidhi Sahni,
- Alejandro A. Gru,
- Brian G. Pierce,
- Abner Louissaint,
- Joan Guitart,
- Jaehyuk Choi
Affiliations
- Jay Daniels
- Department of Dermatology, Northwestern University Feinberg School of Medicine
- Peter G. Doukas
- Department of Dermatology, Northwestern University Feinberg School of Medicine
- Maria E. Martinez Escala
- Department of Dermatology, Northwestern University Feinberg School of Medicine
- Kimberly G. Ringbloom
- Department of Dermatology, Northwestern University Feinberg School of Medicine
- David J. H. Shih
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Jingyi Yang
- Department of Dermatology, Northwestern University Feinberg School of Medicine
- Kyle Tegtmeyer
- Department of Dermatology, Northwestern University Feinberg School of Medicine
- Joonhee Park
- Department of Dermatology, Northwestern University Feinberg School of Medicine
- Jane J. Thomas
- Department of Dermatology, Northwestern University Feinberg School of Medicine
- Mehmet E. Selli
- Department of Dermatology, Northwestern University Feinberg School of Medicine
- Can Altunbulakli
- Department of Dermatology, Northwestern University Feinberg School of Medicine
- Ragul Gowthaman
- University of Maryland Institute for Bioscience and Biotechnology Research
- Samuel H. Mo
- University of Illinois College of Medicine
- Balaji Jothishankar
- Department of Medicine, Section of Dermatology, University of Chicago Pritzker School of Medicine
- David R. Pease
- Department of Dermatology, Northwestern University Feinberg School of Medicine
- Barbara Pro
- Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine
- Farah R. Abdulla
- Division of Dermatology, City of Hope Comprehensive Cancer Center
- Christopher Shea
- Department of Medicine, Section of Dermatology, University of Chicago Pritzker School of Medicine
- Nidhi Sahni
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Alejandro A. Gru
- Department of Pathology, University of Virginia Health System
- Brian G. Pierce
- University of Maryland Institute for Bioscience and Biotechnology Research
- Abner Louissaint
- Department of Pathology, Massachusetts General Hospital
- Joan Guitart
- Department of Dermatology, Northwestern University Feinberg School of Medicine
- Jaehyuk Choi
- Department of Dermatology, Northwestern University Feinberg School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-15572-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Cutaneous gamma-delta T cell lymphomas are rare but aggressive cancers. Here, by DNA, RNA and T cell receptor sequencing, the authors elucidate the molecular ontogeny by revising the cell of origin and identifying potentially targetable mutations.
