Phenotypic Peculiarities of Pathogenic <i>Burkholderia</i> Mutants Resistant to Fluoroquinolones and Cephalosporins

Abstract

Examined were phenotypic peculiarities of mutants of Burkholderia phylogenetically-related pathogenic species (B. pseudomallei, B. mallei, B. cepacia) resistant to fluoroquinolones and cephalosporins. It was shown that strains with PfxR (OfxR), CfzR markers acquire high multi-drug resistance to antibiotics of different classes. Strain resistance changes under blocking influence of verapamil - inhibitor of calcium membrane channels. Mutant strains differ in production of extracellular enzymes (proteases, lecithinase, lipase) and virulence.

Keywords

• <i>burkholderia</i>
• drug resistance
• mutants
• fluoroquinolones
• cephalosporins
• phenotypic peculiarities
• verapamil