SARS-CoV-2 N protein potentiates host NPM1-snoRNA translation machinery to enhance viral replication

Hui Wang; Danrong Shi; Penglei Jiang; Zebin Yu; Yingli Han; Zhaoru Zhang; Peihui Wang; He Huang; Hangping Yao; Pengxu Qian

doi:10.1038/s41392-022-01210-9

Signal Transduction and Targeted Therapy (Oct 2022)

SARS-CoV-2 N protein potentiates host NPM1-snoRNA translation machinery to enhance viral replication

Hui Wang,
Danrong Shi,
Penglei Jiang,
Zebin Yu,
Yingli Han,
Zhaoru Zhang,
Peihui Wang,
He Huang,
Hangping Yao,
Pengxu Qian

Affiliations

Hui Wang: Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
Danrong Shi: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University
Penglei Jiang: Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
Zebin Yu: Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
Yingli Han: Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
Zhaoru Zhang: Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
Peihui Wang: Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University
He Huang: Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
Hangping Yao: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University
Pengxu Qian: Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine

DOI: https://doi.org/10.1038/s41392-022-01210-9
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 4

Abstract

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Published in Signal Transduction and Targeted Therapy

ISSN: 2059-3635 (Online)
Publisher: Nature Publishing Group
Country of publisher: United Kingdom
LCC subjects: Medicine; Science: Biology (General)
Website: http://www.nature.com/sigtrans/

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