Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila

Nikolay P. Kandul; Ting Zhang; Bruce A. Hay; Ming Guo

doi:10.1038/ncomms13100

Nature Communications (Nov 2016)

Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila

Nikolay P. Kandul,
Ting Zhang,
Bruce A. Hay,
Ming Guo

Affiliations

Nikolay P. Kandul: Division of Biology and Biological Engineering, California Institute of Technology
Ting Zhang: Department of Neurology, Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles
Bruce A. Hay: Division of Biology and Biological Engineering, California Institute of Technology
Ming Guo: Department of Neurology, Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles

DOI: https://doi.org/10.1038/ncomms13100
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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Heteroplasmy, in which mutant and wild-type mitochondrial DNA (mtDNA) coexist in a cell, can result in diseases. Here the authors generate transgenic flies with heteroplasmic mtDNA in flight muscles, and show that stimulation of autophagy, or a decrease in mitofusin, promotes clearance of mutant mtDNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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