Nature Communications (Feb 2017)
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects
- Mark Lucanic,
- W. Todd Plummer,
- Esteban Chen,
- Jailynn Harke,
- Anna C. Foulger,
- Brian Onken,
- Anna L. Coleman-Hulbert,
- Kathleen J. Dumas,
- Suzhen Guo,
- Erik Johnson,
- Dipa Bhaumik,
- Jian Xue,
- Anna B. Crist,
- Michael P. Presley,
- Girish Harinath,
- Christine A. Sedore,
- Manish Chamoli,
- Shaunak Kamat,
- Michelle K. Chen,
- Suzanne Angeli,
- Christina Chang,
- John H. Willis,
- Daniel Edgar,
- Mary Anne Royal,
- Elizabeth A. Chao,
- Shobhna Patel,
- Theo Garrett,
- Carolina Ibanez-Ventoso,
- June Hope,
- Jason L Kish,
- Max Guo,
- Gordon J. Lithgow,
- Monica Driscoll,
- Patrick C. Phillips
Affiliations
- Mark Lucanic
- The Buck Institute for Research on Aging
- W. Todd Plummer
- The Buck Institute for Research on Aging
- Esteban Chen
- Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers University
- Jailynn Harke
- Institute of Ecology and Evolution, University of Oregon
- Anna C. Foulger
- The Buck Institute for Research on Aging
- Brian Onken
- Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers University
- Anna L. Coleman-Hulbert
- Institute of Ecology and Evolution, University of Oregon
- Kathleen J. Dumas
- The Buck Institute for Research on Aging
- Suzhen Guo
- Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers University
- Erik Johnson
- Institute of Ecology and Evolution, University of Oregon
- Dipa Bhaumik
- The Buck Institute for Research on Aging
- Jian Xue
- Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers University
- Anna B. Crist
- Institute of Ecology and Evolution, University of Oregon
- Michael P. Presley
- The Buck Institute for Research on Aging
- Girish Harinath
- Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers University
- Christine A. Sedore
- Institute of Ecology and Evolution, University of Oregon
- Manish Chamoli
- The Buck Institute for Research on Aging
- Shaunak Kamat
- Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers University
- Michelle K. Chen
- Institute of Ecology and Evolution, University of Oregon
- Suzanne Angeli
- The Buck Institute for Research on Aging
- Christina Chang
- Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers University
- John H. Willis
- Institute of Ecology and Evolution, University of Oregon
- Daniel Edgar
- The Buck Institute for Research on Aging
- Mary Anne Royal
- Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers University
- Elizabeth A. Chao
- The Buck Institute for Research on Aging
- Shobhna Patel
- Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers University
- Theo Garrett
- The Buck Institute for Research on Aging
- Carolina Ibanez-Ventoso
- Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers University
- June Hope
- The Buck Institute for Research on Aging
- Jason L Kish
- The Buck Institute for Research on Aging
- Max Guo
- Division of Aging Biology, National Institute on Aging
- Gordon J. Lithgow
- The Buck Institute for Research on Aging
- Monica Driscoll
- Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers University
- Patrick C. Phillips
- Institute of Ecology and Evolution, University of Oregon
- DOI
- https://doi.org/10.1038/ncomms14256
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Irreproducibility of biological findings is a major challenge for drug development. Here the authors examine the lifespans of 22 worm strains in three different laboratories and the effects of ten known chemicals to assess reproducibility in the face of variations in genetic background, chemical treatment and lab environment.
