Immunomodulatory role of mesenchymal stem cell therapy in liver fibrosis

Peng Liu; Yerong Qian; Yerong Qian; Xin Liu; Xulong Zhu; Xufeng Zhang; Yi Lv; Yi Lv; Junxi Xiang

doi:10.3389/fimmu.2022.1096402

Frontiers in Immunology (Jan 2023)

Immunomodulatory role of mesenchymal stem cell therapy in liver fibrosis

Peng Liu,
Yerong Qian,
Yerong Qian,
Xin Liu,
Xulong Zhu,
Xufeng Zhang,
Yi Lv,
Yi Lv,
Junxi Xiang

Affiliations

Peng Liu: Center for Regenerative and Reconstructive Medicine, Med-X Institute, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
Yerong Qian: Center for Regenerative and Reconstructive Medicine, Med-X Institute, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
Yerong Qian: Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
Xin Liu: Department of Radiotherapy, Xi’an Medical University, Xi’an, Shaanxi, China
Xulong Zhu: Department of Surgical Oncology, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, China
Xufeng Zhang: Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
Yi Lv: Center for Regenerative and Reconstructive Medicine, Med-X Institute, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
Yi Lv: Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
Junxi Xiang: Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

DOI: https://doi.org/10.3389/fimmu.2022.1096402
Journal volume & issue: Vol. 13

Abstract

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Liver fibrosis is a fibrogenic and inflammatory process that results from hepatocyte injury and is characterized by hepatic architectural distortion and resultant loss of liver function. There is no effective treatment for advanced fibrosis other than liver transplantation, but it is limited by expensive costs, immune rejection, and postoperative complications. With the development of regenerative medicine in recent years, mesenchymal stem cell (MSCs) transplantation has become the most promising treatment for liver fibrosis. The underlying mechanisms of MSC anti-fibrotic effects include hepatocyte differentiation, paracrine, and immunomodulation, with immunomodulation playing a central role. This review discusses the immune cells involved in liver fibrosis, the immunomodulatory properties of MSCs, and the immunomodulation mechanisms of MSC-based strategies to attenuate liver fibrosis. Meanwhile, we discuss the current challenges and future directions as well.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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