Nature Communications (Sep 2017)

PD-L1 is an activation-independent marker of brown adipocytes

  • Jessica R. Ingram,
  • Michael Dougan,
  • Mohammad Rashidian,
  • Marko Knoll,
  • Edmund J. Keliher,
  • Sarah Garrett,
  • Scott Garforth,
  • Olga S. Blomberg,
  • Camilo Espinosa,
  • Atul Bhan,
  • Steven C. Almo,
  • Ralph Weissleder,
  • Harvey Lodish,
  • Stephanie K. Dougan,
  • Hidde L. Ploegh

DOI
https://doi.org/10.1038/s41467-017-00799-8
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Current approaches to visualise brown adipose tissue (BAT) rely primarily on markers that reflect its metabolic activity. Here, the authors show that PD-L1 is expressed on brown adipocytes, does not change upon BAT activation, and that BAT volume in mice can be measured by PET-CT with a radiolabeled anti-PD-L1 antibody.