Neural Regeneration Research (Jan 2015)

c-Jun N-terminal kinase 3 expression in the retina of ocular hypertension mice: a possible target to reduce ganglion cell apoptosis

  • Yue He,
  • Jie Chen,
  • Shu-guang Zhang,
  • Yuan-sheng Yuan,
  • Yan Li,
  • Hong-bin Lv,
  • Jin-hua Gan

DOI
https://doi.org/10.4103/1673-5374.153692
Journal volume & issue
Vol. 10, no. 3
pp. 432 – 437

Abstract

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Glaucoma, a type of optic neuropathy, is characterized by the loss of retinal ganglion cells. It remains controversial whether c-Jun N-terminal kinase (JNK) participates in the apoptosis of retinal ganglion cells in glaucoma. This study sought to explore a possible mechanism of action of JNK signaling pathway in glaucoma-induced retinal optic nerve damage. We established a mouse model of chronic ocular hypertension by reducing the aqueous humor followed by photocoagulation using the laser ignition method. Results showed significant pathological changes in the ocular tissues after the injury. Apoptosis of retinal ganglion cells increased with increased intraocular pressure, as did JNK3 mRNA expression in the retina. These data indicated that the increased expression of JNK3 mRNA was strongly associated with the increase in intraocular pressure in the retina, and correlated positively with the apoptosis of retinal ganglion cells.

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