Pd(PPh3)4 Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug

Jagan Mohana Rao Saketi; S. N. Murthy Boddapati; Raghuram M.; Syed Farooq Adil; Mohammed Rafi Shaik; Osamah Alduhaish; Mohammed Rafiq H. Siddiqui; Hari Babu Bollikolla

doi:10.3390/app10113792

Applied Sciences (May 2020)

Pd(PPh3)4 Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug

Jagan Mohana Rao Saketi,
S. N. Murthy Boddapati,
Raghuram M.,
Syed Farooq Adil,
Mohammed Rafi Shaik,
Osamah Alduhaish,
Mohammed Rafiq H. Siddiqui,
Hari Babu Bollikolla

Affiliations

Jagan Mohana Rao Saketi: Department of Chemistry, Acharya Nagarjuna University, Guntur 522510, India
S. N. Murthy Boddapati: Department of Chemistry, Acharya Nagarjuna University, Guntur 522510, India
Raghuram M.: Department of Botany & Microbiology, Acharya Nagarjuna University, Guntur 522510, India
Syed Farooq Adil: Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Mohammed Rafi Shaik: Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Osamah Alduhaish: Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Mohammed Rafiq H. Siddiqui: Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Hari Babu Bollikolla: Department of Chemistry, Acharya Nagarjuna University, Guntur 522510, India

DOI: https://doi.org/10.3390/app10113792
Journal volume & issue: Vol. 10, no. 11
p. 3792

Abstract

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A series of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields by coupling with several arylboronic acids and methylation by two dissimilar approaches. The as-prepared indazole derivatives (3a–3j) and their N-methyl derivatives (5a–5j) are evaluated for in vitro anticancer activity against two cancer cell lines, HCT-116 and MDA-MB-231. The results reveal that the indazole derivatives tested display mild to moderate anticancer activities against the cell lines tested.

Published in Applied Sciences

ISSN: 2076-3417 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Engineering (General). Civil engineering (General); Science: Biology (General); Science: Physics; Science: Chemistry
Website: http://www.mdpi.com/journal/applsci

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