Nature Communications (May 2021)
Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features
- Anastasia Gangaev,
- Steven L. C. Ketelaars,
- Olga I. Isaeva,
- Sanne Patiwael,
- Anna Dopler,
- Kelly Hoefakker,
- Sara De Biasi,
- Lara Gibellini,
- Cristina Mussini,
- Giovanni Guaraldi,
- Massimo Girardis,
- Cami M. P. Talavera Ormeno,
- Paul J. M. Hekking,
- Neubury M. Lardy,
- Mireille Toebes,
- Robert Balderas,
- Ton N. Schumacher,
- Huib Ovaa,
- Andrea Cossarizza,
- Pia Kvistborg
Affiliations
- Anastasia Gangaev
- Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute
- Steven L. C. Ketelaars
- Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute
- Olga I. Isaeva
- Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute
- Sanne Patiwael
- Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute
- Anna Dopler
- Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute
- Kelly Hoefakker
- Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute
- Sara De Biasi
- University of Modena and Reggio Emilia School of Medicine
- Lara Gibellini
- University of Modena and Reggio Emilia School of Medicine
- Cristina Mussini
- University of Modena and Reggio Emilia School of Medicine
- Giovanni Guaraldi
- University of Modena and Reggio Emilia School of Medicine
- Massimo Girardis
- University of Modena and Reggio Emilia School of Medicine
- Cami M. P. Talavera Ormeno
- Department of Cell and Chemical Biology, Leiden University Medical Center
- Paul J. M. Hekking
- Department of Cell and Chemical Biology, Leiden University Medical Center
- Neubury M. Lardy
- Department of Immunogenetics, Sanquin Diagnostics B.V.
- Mireille Toebes
- Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute
- Robert Balderas
- Department of Biological Sciences, BD Biosciences
- Ton N. Schumacher
- Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute
- Huib Ovaa
- Department of Cell and Chemical Biology, Leiden University Medical Center
- Andrea Cossarizza
- University of Modena and Reggio Emilia School of Medicine
- Pia Kvistborg
- Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-021-22811-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Many viral antigens have been identified in patients with COVID-19 patients, but which of these result in meaningful immune responses is unclear. Here the authors identify a range of SARS-CoV-2 CD8+ T cell responses across patients including a response targeting an epitope of ORF1ab with immunodominant properties.
