Nature Communications (May 2017)
Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations
- Jiang Chang,
- Wenle Tan,
- Zhiqiang Ling,
- Ruibin Xi,
- Mingming Shao,
- Mengjie Chen,
- Yingying Luo,
- Yanjie Zhao,
- Yun Liu,
- Xiancong Huang,
- Yuchao Xia,
- Jinlin Hu,
- Joel S. Parker,
- David Marron,
- Qionghua Cui,
- Linna Peng,
- Jiahui Chu,
- Hongmin Li,
- Zhongli Du,
- Yaling Han,
- Wen Tan,
- Zhihua Liu,
- Qimin Zhan,
- Yun Li,
- Weimin Mao,
- Chen Wu,
- Dongxin Lin
Affiliations
- Jiang Chang
- Key Laboratory for Environment and Health (Ministry of Education), School of Public Health, Huazhong University of Science and Technology
- Wenle Tan
- Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Zhiqiang Ling
- Cancer Institute, Zhejiang Cancer Hospital
- Ruibin Xi
- Department of Probability and Statistics, School of Mathematical Sciences and Center for Statistical Science, Peking University
- Mingming Shao
- Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Mengjie Chen
- Department of Genetics, University of North Carolina
- Yingying Luo
- Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Yanjie Zhao
- Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Yun Liu
- Department of Probability and Statistics, School of Mathematical Sciences and Center for Statistical Science, Peking University
- Xiancong Huang
- Cancer Institute, Zhejiang Cancer Hospital
- Yuchao Xia
- Department of Probability and Statistics, School of Mathematical Sciences and Center for Statistical Science, Peking University
- Jinlin Hu
- Department of Pathology, Zhejiang Cancer Hospital
- Joel S. Parker
- Department of Genetics, University of North Carolina
- David Marron
- Department of Computer Science, University of North Carolina
- Qionghua Cui
- Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Linna Peng
- Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Jiahui Chu
- Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Hongmin Li
- Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Zhongli Du
- Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Yaling Han
- Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Wen Tan
- Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Zhihua Liu
- State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Qimin Zhan
- State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Yun Li
- Department of Genetics, University of North Carolina
- Weimin Mao
- Department of Thoracic Surgery, Zhejiang Cancer Hospital
- Chen Wu
- Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Dongxin Lin
- Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- DOI
- https://doi.org/10.1038/ncomms15290
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Oesophageal squamous-cell carcinoma (ESCC) is a leading cause of cancer death, and half of ESCC cases occur in China. Here, the authors provide an in depth genomic landscape for this disease and identify specific mutation signatures—one of which is linked to alcohol intake.
