Communications Medicine (Mar 2024)
Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors
- Bertram Kjerulff,
- Joseph Dowsett,
- Rikke Louise Jacobsen,
- Josephine Gladov,
- Margit Hørup Larsen,
- Agnete Troen Lundgaard,
- Karina Banasik,
- David Westergaard,
- Susan Mikkelsen,
- Khoa Manh Dinh,
- Lotte Hindhede,
- Kathrine Agergård Kaspersen,
- Michael Schwinn,
- Anders Juul,
- Betina Poulsen,
- Birgitte Lindegaard,
- Carsten Bøcker Pedersen,
- Clive Eric Sabel,
- Henning Bundgaard,
- Henriette Svarre Nielsen,
- Janne Amstrup Møller,
- Jens Kjærgaard Boldsen,
- Kristoffer Sølvsten Burgdorf,
- Lars Vedel Kessing,
- Linda Jenny Handgaard,
- Lise Wegner Thørner,
- Maria Didriksen,
- Mette Nyegaard,
- Niels Grarup,
- Niels Ødum,
- Pär I. Johansson,
- Poul Jennum,
- Ruth Frikke-Schmidt,
- Sanne Schou Berger,
- Søren Brunak,
- Søren Jacobsen,
- Thomas Folkmann Hansen,
- Tine Kirkeskov Lundquist,
- Torben Hansen,
- Torben Lykke Sørensen,
- Torben Sigsgaard,
- Kaspar René Nielsen,
- Mie Topholm Bruun,
- Henrik Hjalgrim,
- Henrik Ullum,
- Klaus Rostgaard,
- Erik Sørensen,
- Ole Birger Pedersen,
- Sisse Rye Ostrowski,
- Christian Erikstrup
Affiliations
- Bertram Kjerulff
- Department of Clinical Immunology, Aarhus University Hospital
- Joseph Dowsett
- Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet
- Rikke Louise Jacobsen
- Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet
- Josephine Gladov
- Department of Clinical Immunology, Aarhus University Hospital
- Margit Hørup Larsen
- Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet
- Agnete Troen Lundgaard
- Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Karina Banasik
- Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- David Westergaard
- Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Susan Mikkelsen
- Department of Clinical Immunology, Aarhus University Hospital
- Khoa Manh Dinh
- Department of Clinical Immunology, Aarhus University Hospital
- Lotte Hindhede
- Department of Clinical Immunology, Aarhus University Hospital
- Kathrine Agergård Kaspersen
- Department of Clinical Immunology, Aarhus University Hospital
- Michael Schwinn
- Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet
- Anders Juul
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Betina Poulsen
- Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet
- Birgitte Lindegaard
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Carsten Bøcker Pedersen
- BERTHA Big Data Centre for Environment and Health, Aarhus University
- Clive Eric Sabel
- BERTHA Big Data Centre for Environment and Health, Aarhus University
- Henning Bundgaard
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Henriette Svarre Nielsen
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Janne Amstrup Møller
- Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet
- Jens Kjærgaard Boldsen
- Department of Clinical Immunology, Aarhus University Hospital
- Kristoffer Sølvsten Burgdorf
- Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Lars Vedel Kessing
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Linda Jenny Handgaard
- Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet
- Lise Wegner Thørner
- Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet
- Maria Didriksen
- Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet
- Mette Nyegaard
- Department of Health Science and Technology, Aalborg University
- Niels Grarup
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Niels Ødum
- LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen
- Pär I. Johansson
- Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet
- Poul Jennum
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Ruth Frikke-Schmidt
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Sanne Schou Berger
- Centre for Diagnostics, DTU Health Technology, Technical University of Denmark
- Søren Brunak
- Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Søren Jacobsen
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Thomas Folkmann Hansen
- Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Tine Kirkeskov Lundquist
- Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet
- Torben Hansen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Torben Lykke Sørensen
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Torben Sigsgaard
- BERTHA Big Data Centre for Environment and Health, Aarhus University
- Kaspar René Nielsen
- Department of Clinical Immunology, Aalborg University Hospital
- Mie Topholm Bruun
- Department of Clinical Immunology, Odense University Hospital
- Henrik Hjalgrim
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Henrik Ullum
- Statens Serum Institut
- Klaus Rostgaard
- Department of Epidemiology Research, Statens Serum Institut
- Erik Sørensen
- Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet
- Ole Birger Pedersen
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Sisse Rye Ostrowski
- Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet
- Christian Erikstrup
- Department of Clinical Immunology, Aarhus University Hospital
- DOI
- https://doi.org/10.1038/s43856-024-00474-2
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 15
Abstract
Abstract Background The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences. Methods A selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined the association between biomarkers and sex, age, Body Mass Index (BMI), and smoking. Results Here we show that concentrations of inflammation and vascular stress biomarkers generally increase with higher age, BMI, and smoking. Sex-specific effects are observed for multiple biomarkers. Conclusion This study provides comprehensive information on concentrations of 47 plasma biomarkers in healthy individuals. The study emphasizes that knowledge about biomarker concentrations in healthy individuals is critical for improved understanding of disease pathology and for tailored care and decision support tools.
