P3.8 ARTERIAL STIFFNESS AND LEFT ATRIAL VOLUME IN HYPERTENSIVE AND NORMOTENSIVE SUBJECTS

Abstract

Aim: Investigation of relationship between arterial stiffness indices and LAVI in hypertensive and normotensive subjects. Material and methods: Patients were recruited among Morawica town inhabitants. Study group (AH) consisted of 41 untreated hypertensives (20 men). Control group (NonAH)consisted of 60 normotensives (32 men). Anthropometric and demographic data were collected via questionnaire. Following examinations were performed: office blood pressure measurement (SBP, DBP) using Omron M5-I; arterial stiffness measurements i.e. carotid-femoral pulse wave velocity (PWV) and central blood pressure (cSBP, cDBP) using SphygmoCor® device; echocardiographic left atrium volume determination (LAV) using VIVID-7 GE device followed by LAVI calculation (LAVI = LAV/body surface area). Results: AH group was older (56,9±6,9 vs 50,2±7,9 yrs, p=0,0002) exhibiting higher BMI (28,2±9,0 vs 26,3± 5,9 kg/m2, p=0,03) and higher office SBP (149,5±15,7 vs 138,6±20,1 mmHg, p=0,04) and DBP (91,1±8,4 vs 85,7±12,8, p=0,02). PWV did not differ in investigated groups, while cSBP (136,3±15,0 vs 126,8±20,0 mmHg, p=0,02) and cDBP (90,8±7,0 vs 84,9±12,3 mmHg, p=0,01) were higher in AH group. LAVI was significantly higher in AH group than in NonAH group (27,8±9,5 vs 24,3±6,6 ml/m2, p=0,003). Among AH group LAVI correlated positively only with cSBP (r=0,33, p= 0,04). Among NonAH group, LAVI correlated positively with age (r=0,27, p=0,03), BMI (r=0,39, p=0,02) and cSBP (r=0,27, p=0,35). Conclusions: Hypertensive subjects represent higher values of LAVI. In this group LAVI depends mainly on central systolic blood pressure, while in the group of normotensives LAVI is additionally determined by age and body mass index.