Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior

Li-Pao Fang; Na Zhao; Laura C. Caudal; Hsin-Fang Chang; Renping Zhao; Ching-Hsin Lin; Nadine Hainz; Carola Meier; Bernhard Bettler; Wenhui Huang; Anja Scheller; Frank Kirchhoff; Xianshu Bai

doi:10.1038/s41467-022-29020-1

Nature Communications (Mar 2022)

Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior

Li-Pao Fang,
Na Zhao,
Laura C. Caudal,
Hsin-Fang Chang,
Renping Zhao,
Ching-Hsin Lin,
Nadine Hainz,
Carola Meier,
Bernhard Bettler,
Wenhui Huang,
Anja Scheller,
Frank Kirchhoff,
Xianshu Bai

Affiliations

Li-Pao Fang: Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland
Na Zhao: Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland
Laura C. Caudal: Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland
Hsin-Fang Chang: Cellular Neurophysiology, CIPMM, University of Saarland
Renping Zhao: Biophysics, CIPMM, University of Saarland
Ching-Hsin Lin: Cellular Neurophysiology, CIPMM, University of Saarland
Nadine Hainz: Department of Anatomy and Cell Biology, University of Saarland
Carola Meier: Department of Anatomy and Cell Biology, University of Saarland
Bernhard Bettler: Department of Biomedicine, University of Basel
Wenhui Huang: Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland
Anja Scheller: Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland
Frank Kirchhoff: Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland
Xianshu Bai: Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland

DOI: https://doi.org/10.1038/s41467-022-29020-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

Read online

Early postnatal interruption of the bidirectional GABA/TNFSF12 signaling between parvalbumin-positive interneurons and oligodendrocyte precursor cells impairs correct prefrontal cortical network activity and social cognitive behavior later in life.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal