Haematologica (Jul 2010)

The t(14;20) is a poor prognostic factor in myeloma but is associated with long-term stable disease in monoclonal gammopathies of undetermined significance

  • Fiona M. Ross,
  • Laura Chiecchio,
  • GianPaolo Dagrada,
  • Rebecca K.M. Protheroe,
  • David M. Stockley,
  • Christine J. Harrison,
  • Nicholas C.P. Cross,
  • Alex J. Szubert,
  • Mark T. Drayson,
  • Gareth J. Morgan

DOI
https://doi.org/10.3324/haematol.2009.016329
Journal volume & issue
Vol. 95, no. 7

Abstract

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A large series of plasma cell dyscrasias (n=2207) was examined for translocations which deregulate the MAF genes, t(14;20)(q32;q12) and t(14;16)(q32;q23), and their disease behavior was compared to a group characterized by the t(4;14)(p16;q32) where CCND2 is also up-regulated. The t(14;20) showed low prevalence in myeloma (27/1830, 1.5%) and smoldering myeloma (1/148,