Drug Compatibility in Treatment of Chronic Infectious Diseases

Abstract

The article considers the features of pharmacotherapy of patients with chronic infectious diseases and co-morbidities in conditions of polypharmacy, the principles of drug metabolism, variants of adverse effects and drug-drug interactions, the possibilities of effective drug combinations. The purpose is to substantiate the possibility and emphasize the relevance of the additional search of the creation of the most optimal combinations of drugs for long-term and massive pharmacotherapy, that could be due to a beneficial drug-drug interaction, optimization of the regimen, route of drug administration and multitarget of the therapeutic effect, reduce the pharmacological load while maintaining the effectiveness of the treatment, increase patient adherence to drug therapy.

Keywords

• лекарственная совместимость
• межлекарственное взаимодействие
• фармакотерапия
• полипрагмазия
• хронические инфекционные болезни
• вич-инфекция
• антиретровирусная терапия
• туберкулез
• коморбидность