Communications Biology (Sep 2022)
HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2
- Thorunn A. Olafsdottir,
- Kristbjorg Bjarnadottir,
- Gudmundur L. Norddahl,
- Gisli H. Halldorsson,
- Pall Melsted,
- Kristbjorg Gunnarsdottir,
- Erna Ivarsdottir,
- Thorhildur Olafsdottir,
- Asgeir O. Arnthorsson,
- Fannar Theodors,
- Elias Eythorsson,
- Dadi Helgason,
- Hannes P. Eggertsson,
- Gisli Masson,
- Sólveig Bjarnadottir,
- Saedis Saevarsdottir,
- Hrafnhildur L. Runolfsdottir,
- Isleifur Olafsson,
- Jona Saemundsdottir,
- Martin I. Sigurdsson,
- Ragnar F. Ingvarsson,
- Runolfur Palsson,
- Gudmundur Thorgeirsson,
- Bjarni V. Halldorsson,
- Hilma Holm,
- Mar Kristjansson,
- Patrick Sulem,
- Unnur Thorsteinsdottir,
- Ingileif Jonsdottir,
- Daniel F. Gudbjartsson,
- Kari Stefansson
Affiliations
- Thorunn A. Olafsdottir
- deCODE genetics/Amgen Inc.
- Kristbjorg Bjarnadottir
- deCODE genetics/Amgen Inc.
- Gudmundur L. Norddahl
- deCODE genetics/Amgen Inc.
- Gisli H. Halldorsson
- deCODE genetics/Amgen Inc.
- Pall Melsted
- deCODE genetics/Amgen Inc.
- Kristbjorg Gunnarsdottir
- deCODE genetics/Amgen Inc.
- Erna Ivarsdottir
- deCODE genetics/Amgen Inc.
- Thorhildur Olafsdottir
- deCODE genetics/Amgen Inc.
- Asgeir O. Arnthorsson
- deCODE genetics/Amgen Inc.
- Fannar Theodors
- deCODE genetics/Amgen Inc.
- Elias Eythorsson
- Internal Medicine and Emergency Services, Landspitali – The National University Hospital of Iceland
- Dadi Helgason
- Internal Medicine and Emergency Services, Landspitali – The National University Hospital of Iceland
- Hannes P. Eggertsson
- deCODE genetics/Amgen Inc.
- Gisli Masson
- deCODE genetics/Amgen Inc.
- Sólveig Bjarnadottir
- Internal Medicine and Emergency Services, Landspitali – The National University Hospital of Iceland
- Saedis Saevarsdottir
- deCODE genetics/Amgen Inc.
- Hrafnhildur L. Runolfsdottir
- Internal Medicine and Emergency Services, Landspitali – The National University Hospital of Iceland
- Isleifur Olafsson
- Clinical Laboratory Services, Diagnostics and Blood Bank, Landspitali – The National University Hospital of Iceland
- Jona Saemundsdottir
- deCODE genetics/Amgen Inc.
- Martin I. Sigurdsson
- Faculty of Medicine, School of Health Sciences, University of Iceland
- Ragnar F. Ingvarsson
- Internal Medicine and Emergency Services, Landspitali – The National University Hospital of Iceland
- Runolfur Palsson
- Internal Medicine and Emergency Services, Landspitali – The National University Hospital of Iceland
- Gudmundur Thorgeirsson
- deCODE genetics/Amgen Inc.
- Bjarni V. Halldorsson
- deCODE genetics/Amgen Inc.
- Hilma Holm
- deCODE genetics/Amgen Inc.
- Mar Kristjansson
- Internal Medicine and Emergency Services, Landspitali – The National University Hospital of Iceland
- Patrick Sulem
- deCODE genetics/Amgen Inc.
- Unnur Thorsteinsdottir
- deCODE genetics/Amgen Inc.
- Ingileif Jonsdottir
- deCODE genetics/Amgen Inc.
- Daniel F. Gudbjartsson
- deCODE genetics/Amgen Inc.
- Kari Stefansson
- deCODE genetics/Amgen Inc.
- DOI
- https://doi.org/10.1038/s42003-022-03893-w
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 14
Abstract
A study of 768 convalescent SARS CoV-2-infected and 500 uninfected Icelanders reveals broad and stable T-cell responses 3-8 months from infection. HLA alleles, disease severity, and age contribute to the heterogeneity of cellular immunity.
