Nature Communications (Sep 2022)
Serum neutralization activity declines but memory B cells persist after cure of chronic hepatitis C
- Akira Nishio,
- Sharika Hasan,
- Heiyoung Park,
- Nana Park,
- Jordan H. Salas,
- Eduardo Salinas,
- Lela Kardava,
- Paul Juneau,
- Nicole Frumento,
- Guido Massaccesi,
- Susan Moir,
- Justin R. Bailey,
- Arash Grakoui,
- Marc G. Ghany,
- Barbara Rehermann
Affiliations
- Akira Nishio
- Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS
- Sharika Hasan
- Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS
- Heiyoung Park
- Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS
- Nana Park
- Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS
- Jordan H. Salas
- Department of Medicine, Johns Hopkins University School of Medicine
- Eduardo Salinas
- Division of Infectious Diseases, Emory Vaccine Center, Division of Microbiology and Immunology, Emory University School of Medicine
- Lela Kardava
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS
- Paul Juneau
- Division of Data Services, NIH Library, Office of Research Services, National Institutes of Health
- Nicole Frumento
- Department of Medicine, Johns Hopkins University School of Medicine
- Guido Massaccesi
- Department of Medicine, Johns Hopkins University School of Medicine
- Susan Moir
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS
- Justin R. Bailey
- Department of Medicine, Johns Hopkins University School of Medicine
- Arash Grakoui
- Division of Infectious Diseases, Emory Vaccine Center, Division of Microbiology and Immunology, Emory University School of Medicine
- Marc G. Ghany
- Clinical Research Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS
- Barbara Rehermann
- Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS
- DOI
- https://doi.org/10.1038/s41467-022-33035-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Long-term dynamics of the humoral response to HCV in cured individuals aren’t well understood. Here, Nishio et al. show that virus-neutralizing antibody levels decrease in potency and breadth after cure of chronic hepatitis C, while HCV-specific memory B cells persist.
