Correlation of vitamin D deficiency and anti-mullerian hormone levels in infertile females

Abstract

Objectives: 1. To analyse the levels of vitamin D in infertile females, 2. To analyse the levels of Anti-Mullerian Hormone (AMH) in infertile females, 3. To correlate the vitamin D deficiency levels and AMH levels in infertile females. Methods: It was a hospital based cross-sectional study among 100 infertile females of the age group 18-40 years presenting at the Gynae OPD of Gauhati Medical College and Hospital, conducted between 1st June, 2019 and 31st May, 2020. Results: Of the infertile females, 46% were vitamin D deficient, 36% had insufficient vitamin D levels while 18% were sufficient in vitamin D. Majority of the study population (66%) belonged to the age group of 21-30 years. In the study group, 35% patients were in the normal weight range, while 39% patients were overweight and 26% females were obese I category. Of the infertile females, 81% had normal AMH values, while 7% had low AMH values and 12% had raised AMH levels. The mean AMH levels were not statistically significant between the vitamin D deficient females and those without deficiency. Conclusion: The existence of vitamin D responsive elements on the AMH gene promoter provides a scientific basis for vitamin D to exert its effects on AMH gene expression levels. However, our study could not find any correlation between vitamin D and AMH levels in the infertile females.

Keywords

• infertility
• vitamin d
• anti-mullerian hormone