African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

Abstract

A polymorphism in human TP53 (P47S) that predominantly exists in individuals of African descent affects ferroptosis. Here, the authors show that this results in iron accumulation in macrophages leading to more productive infection by intracellular bacteria but improved anti-inflammatory response to the malarial toxin hemozoin.