Nature Communications (Jan 2022)
Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps
- Coline Plé,
- Heng-Keat Tam,
- Anais Vieira Da Cruz,
- Nina Compagne,
- Juan-Carlos Jiménez-Castellanos,
- Reinke T. Müller,
- Elizabeth Pradel,
- Wuen Ee Foong,
- Giuliano Malloci,
- Alexia Ballée,
- Moritz A. Kirchner,
- Parisa Moshfegh,
- Adrien Herledan,
- Andrea Herrmann,
- Benoit Deprez,
- Nicolas Willand,
- Attilio Vittorio Vargiu,
- Klaas M. Pos,
- Marion Flipo,
- Ruben C. Hartkoorn
Affiliations
- Coline Plé
- Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur Lille, U1019—UMR 9017—CIIL—Center for Infection and Immunity of Lille
- Heng-Keat Tam
- Institute of Biochemistry, Goethe-University Frankfurt
- Anais Vieira Da Cruz
- Univ. Lille, Inserm, Institut Pasteur de Lille, U1177—Drugs and Molecules for Living Systems
- Nina Compagne
- Univ. Lille, Inserm, Institut Pasteur de Lille, U1177—Drugs and Molecules for Living Systems
- Juan-Carlos Jiménez-Castellanos
- Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur Lille, U1019—UMR 9017—CIIL—Center for Infection and Immunity of Lille
- Reinke T. Müller
- Institute of Biochemistry, Goethe-University Frankfurt
- Elizabeth Pradel
- Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur Lille, U1019—UMR 9017—CIIL—Center for Infection and Immunity of Lille
- Wuen Ee Foong
- Institute of Biochemistry, Goethe-University Frankfurt
- Giuliano Malloci
- Department of Physics, University of Cagliari
- Alexia Ballée
- Univ. Lille, Inserm, Institut Pasteur de Lille, U1177—Drugs and Molecules for Living Systems
- Moritz A. Kirchner
- Institute of Biochemistry, Goethe-University Frankfurt
- Parisa Moshfegh
- Univ. Lille, Inserm, Institut Pasteur de Lille, U1177—Drugs and Molecules for Living Systems
- Adrien Herledan
- Univ. Lille, Inserm, Institut Pasteur de Lille, U1177—Drugs and Molecules for Living Systems
- Andrea Herrmann
- Institute of Biochemistry, Goethe-University Frankfurt
- Benoit Deprez
- Univ. Lille, Inserm, Institut Pasteur de Lille, U1177—Drugs and Molecules for Living Systems
- Nicolas Willand
- Univ. Lille, Inserm, Institut Pasteur de Lille, U1177—Drugs and Molecules for Living Systems
- Attilio Vittorio Vargiu
- Department of Physics, University of Cagliari
- Klaas M. Pos
- Institute of Biochemistry, Goethe-University Frankfurt
- Marion Flipo
- Univ. Lille, Inserm, Institut Pasteur de Lille, U1177—Drugs and Molecules for Living Systems
- Ruben C. Hartkoorn
- Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur Lille, U1019—UMR 9017—CIIL—Center for Infection and Immunity of Lille
- DOI
- https://doi.org/10.1038/s41467-021-27726-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-negative bacteria. Here, the authors identify pyridylpiperazine-based compounds that potentiate antibiotic activity in E. coli through allosteric inhibition of its primary RND transporter.
