Modulation of telomere protection by the PI3K/AKT pathway

Marinela Méndez-Pertuz; Paula Martínez; Carmen Blanco-Aparicio; Elena Gómez-Casero; Ana Belen García; Jorge Martínez-Torrecuadrada; Marta Palafox; Javier Cortés; Violeta Serra; Joaquin Pastor; Maria A. Blasco

doi:10.1038/s41467-017-01329-2

Nature Communications (Nov 2017)

Modulation of telomere protection by the PI3K/AKT pathway

Marinela Méndez-Pertuz,
Paula Martínez,
Carmen Blanco-Aparicio,
Elena Gómez-Casero,
Ana Belen García,
Jorge Martínez-Torrecuadrada,
Marta Palafox,
Javier Cortés,
Violeta Serra,
Joaquin Pastor,
Maria A. Blasco

Affiliations

Marinela Méndez-Pertuz: Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO)
Paula Martínez: Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO)
Carmen Blanco-Aparicio: Experimental Therapeutics Program, Spanish National Cancer Centre (CNIO)
Elena Gómez-Casero: Experimental Therapeutics Program, Spanish National Cancer Centre (CNIO)
Ana Belen García: Experimental Therapeutics Program, Spanish National Cancer Centre (CNIO)
Jorge Martínez-Torrecuadrada: Biotechnology Program, Spanish National Cancer Centre (CNIO)
Marta Palafox: Experimental Therapeutics Group, Vall d´Hebron Institute of Oncology (VHIO)
Javier Cortés: Experimental Therapeutics Group, Vall d´Hebron Institute of Oncology (VHIO)
Violeta Serra: Experimental Therapeutics Group, Vall d´Hebron Institute of Oncology (VHIO)
Joaquin Pastor: Experimental Therapeutics Program, Spanish National Cancer Centre (CNIO)
Maria A. Blasco: Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO)

DOI: https://doi.org/10.1038/s41467-017-01329-2
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 17

Abstract

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Regulation of telomeres and the insulin/PI3K pathway both have roles in aging and cancer development but have not been functionally linked. Here the authors demonstrate that PI3K, via downstream targets, regulates TRF1 via phosphorylation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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