Environment International (Oct 2022)
Developing human biomonitoring as a 21st century toolbox within the European exposure science strategy 2020–2030
- Maryam Zare Jeddi,
- Nancy B. Hopf,
- Henriqueta Louro,
- Susana Viegas,
- Karen S. Galea,
- Robert Pasanen-Kase,
- Tiina Santonen,
- Vicente Mustieles,
- Mariana F. Fernandez,
- Hans Verhagen,
- Stephanie K. Bopp,
- Jean Philippe Antignac,
- Arthur David,
- Hans Mol,
- Robert Barouki,
- Karine Audouze,
- Radu-Corneliu Duca,
- Peter Fantke,
- Paul Scheepers,
- Manosij Ghosh,
- An Van Nieuwenhuyse,
- Joana Lobo Vicente,
- Xenia Trier,
- Loïc Rambaud,
- Clémence Fillol,
- Sebastien Denys,
- André Conrad,
- Marike Kolossa-Gehring,
- Alicia Paini,
- Jon Arnot,
- Florian Schulze,
- Kate Jones,
- Ovnair Sepai,
- Imran Ali,
- Lorraine Brennan,
- Emilio Benfenati,
- Francesco Cubadda,
- Alberto Mantovani,
- Alena Bartonova,
- Alison Connolly,
- Jaroslav Slobodnik,
- Yuri Bruinen de Bruin,
- Jacob van Klaveren,
- Nicole Palmen,
- Hubert Dirven,
- Trine Husøy,
- Cathrine Thomsen,
- Ana Virgolino,
- Martin Röösli,
- Tim Gant,
- Natalie von Goetz,
- Jos Bessems
Affiliations
- Maryam Zare Jeddi
- National Institute for Public Health and the Environment (RIVM), the Netherlands; Corresponding author.
- Nancy B. Hopf
- Centre for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland
- Henriqueta Louro
- National Institute of Health Dr. Ricardo Jorge, Department of Human Genetics, Lisbon and ToxOmics – Centre for Toxicogenomics and Human Health, NOVA Medical School, Universidade NOVA de Lisboa, Lisbon, Portugal
- Susana Viegas
- NOVA National School of Public Health, Public Health Research Centre, Universidade NOVA de Lisboa, 1600–560 Lisbon, Portugal; Comprehensive Health Research Center (CHRC), 1169–056 Lisbon, Portugal
- Karen S. Galea
- Institute of Occupational Medicine (IOM), Research Avenue North, Riccarton, Edinburgh EH14 4AP, UK
- Robert Pasanen-Kase
- State Secretariat for Economic Affairs (SECO), Labour Directorate Section Chemicals and Work (ABCH), Switzerland
- Tiina Santonen
- Finnish Institute of Occupational Health (FIOH), P.O. Box 40, FI-00032 Työterveyslaitos, Finland
- Vicente Mustieles
- University of Granada, Center for Biomedical Research (CIBM), School of Medicine, Department of Radiology and Physical Medicine, Granada, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Madrid, Spain
- Mariana F. Fernandez
- University of Granada, Center for Biomedical Research (CIBM), School of Medicine, Department of Radiology and Physical Medicine, Granada, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Madrid, Spain
- Hans Verhagen
- University of Ulster, Coleraine, Northern Ireland, National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark
- Stephanie K. Bopp
- European Commission, Joint Research Centre (JRC), Ispra, Italy
- Jean Philippe Antignac
- Oniris, INRAE, LABERCA, Nantes, France
- Arthur David
- Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), UMR_S 1085, F-35000 Rennes, France
- Hans Mol
- Wageningen Food Safety Research – part of Wageningen University & Research, Wageningen, the Netherlands
- Robert Barouki
- Université Paris Cité, T3S, Inserm Unit 1124, 45 rue des Saints Pères, 75006 Paris, France
- Karine Audouze
- Université Paris Cité, T3S, Inserm Unit 1124, 45 rue des Saints Pères, 75006 Paris, France
- Radu-Corneliu Duca
- Department of Health Protection, Laboratoire national de santé (LNS), 1, Rue Louis Rech, 3555 Dudelange, Luxembourg; Environment and Health, Department of Public Health and Primary Care, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
- Peter Fantke
- Quantitative Sustainability Assessment, Department of Environmental and Resource Engineering, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
- Paul Scheepers
- Radboud Institute for Biological and Environmental Sciences, Radboud University, Nijmegen, the Netherlands
- Manosij Ghosh
- Environment and Health, Department of Public Health and Primary Care, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
- An Van Nieuwenhuyse
- Department of Health Protection, Laboratoire national de santé (LNS), 1, Rue Louis Rech, 3555 Dudelange, Luxembourg; Environment and Health, Department of Public Health and Primary Care, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
- Joana Lobo Vicente
- EEA - European Environment Agency, Kongens Nytorv 6, 1050 Copenhagen K, Denmark
- Xenia Trier
- SPF - Santé Publique France, Environmental and Occupational Health Division, France
- Loïc Rambaud
- SPF - Santé Publique France, Environmental and Occupational Health Division, France
- Clémence Fillol
- SPF - Santé Publique France, Environmental and Occupational Health Division, France
- Sebastien Denys
- SPF - Santé Publique France, Environmental and Occupational Health Division, France
- André Conrad
- German Environment Agency (Umweltbundesamt), Dessau-Roßlau/Berlin, Germany
- Marike Kolossa-Gehring
- German Environment Agency (Umweltbundesamt), Dessau-Roßlau/Berlin, Germany
- Alicia Paini
- European Commission, Joint Research Centre (JRC), Ispra, Italy
- Jon Arnot
- ARC Arnot Research and Consulting, Inc., Toronto ONM4M 1W4, Canada
- Florian Schulze
- European Center for Environmental Medicine, Weserstr. 165, 12045 Berlin, Germany
- Kate Jones
- HSE - Health and Safety Executive, Harpur Hill, Buxton SK17 9JN, UK
- Ovnair Sepai
- Public Health England, UK
- Imran Ali
- KEMI, Swedish Chemical Agency
- Lorraine Brennan
- School of Agriculture and Food Science, Institute of Food and Health, University College Dublin, Dublin, Ireland
- Emilio Benfenati
- Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milano, Italy
- Francesco Cubadda
- Istituto Superiore di Sanità - National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy
- Alberto Mantovani
- Istituto Superiore di Sanità - National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy
- Alena Bartonova
- NILU Norwegian Institute for Air Research, 2027 Kjeller, Norway
- Alison Connolly
- Centre for Climate and Air Pollution Studies, Physics, School of Natural Science and the Ryan Institute, University of Galway, University Road, Galway H91 CF50, Ireland
- Jaroslav Slobodnik
- NORMAN Association, Rue Jacques Taffanel – Parc Technologique ALATA, 60550 Verneuil-en-Halatte, France
- Yuri Bruinen de Bruin
- Commission, Joint Research Centre, Directorate for Space, Security and Migration, Geel, Belgium
- Jacob van Klaveren
- National Institute for Public Health and the Environment (RIVM), the Netherlands
- Nicole Palmen
- National Institute for Public Health and the Environment (RIVM), the Netherlands
- Hubert Dirven
- Department of Environmental Health, Norwegian Institute of Public Health, Oslo, Norway
- Trine Husøy
- Department of Environmental Health, Norwegian Institute of Public Health, Oslo, Norway
- Cathrine Thomsen
- Department of Environmental Health, Norwegian Institute of Public Health, Oslo, Norway
- Ana Virgolino
- Environmental Health Behaviour Lab, Instituto de Saúde Ambiental, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal; Laboratório Associado TERRA, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal
- Martin Röösli
- Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute (Swiss TPH), CH-4123 Allschwil, Switzerland
- Tim Gant
- Center for Radiation, Chemical and Environmental Hazards, Public Health England, UK
- Natalie von Goetz
- FOPH, Federal Office of Public Health, CH-3003 Bern, Switzerland
- Jos Bessems
- VITO HEALTH, Flemish Institute for Technological Research, 2400 Mol, Belgium
- Journal volume & issue
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Vol. 168
p. 107476
Abstract
Human biomonitoring (HBM) is a crucial approach for exposure assessment, as emphasised in the European Commission’s Chemicals Strategy for Sustainability (CSS). HBM can help to improve chemical policies in five major key areas: (1) assessing internal and aggregate exposure in different target populations; 2) assessing exposure to chemicals across life stages; (3) assessing combined exposure to multiple chemicals (mixtures); (4) bridging regulatory silos on aggregate exposure; and (5) enhancing the effectiveness of risk management measures.In this strategy paper we propose a vision and a strategy for the use of HBM in chemical regulations and public health policy in Europe and beyond. We outline six strategic objectives and a roadmap to further strengthen HBM approaches and increase their implementation in the regulatory risk assessment of chemicals to enhance our understanding of exposure and health impacts, enabling timely and targeted policy interventions and risk management. These strategic objectives are: 1) further development of sampling strategies and sample preparation; 2) further development of chemical-analytical HBM methods; 3) improving harmonisation throughout the HBM research life cycle; 4) further development of quality control / quality assurance throughout the HBM research life cycle; 5) obtain sustained funding and reinforcement by legislation; and 6) extend target-specific communication with scientists, policymakers, citizens and other stakeholders.HBM approaches are essential in risk assessment to address scientific, regulatory and societal challenges. HBM requires full and strong support from the scientific and regulatory domain to reach its full potential in public and occupational health assessment and in regulatory decision-making.
