Nature Communications (Jul 2022)
Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade
- Gurman Kaur,
- Caroline B. M. Porter,
- Orr Ashenberg,
- Jack Lee,
- Samantha J. Riesenfeld,
- Matan Hofree,
- Maria Aggelakopoulou,
- Ayshwarya Subramanian,
- Subita Balaram Kuttikkatte,
- Kathrine E. Attfield,
- Christiane A. E. Desel,
- Jessica L. Davies,
- Hayley G. Evans,
- Inbal Avraham-Davidi,
- Lan T. Nguyen,
- Danielle A. Dionne,
- Anna E. Neumann,
- Lise Torp Jensen,
- Thomas R. Barber,
- Elizabeth Soilleux,
- Mary Carrington,
- Gil McVean,
- Orit Rozenblatt-Rosen,
- Aviv Regev,
- Lars Fugger
Affiliations
- Gurman Kaur
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- Caroline B. M. Porter
- Klarman Cell Observatory, Broad Institute of MIT and Harvard
- Orr Ashenberg
- Klarman Cell Observatory, Broad Institute of MIT and Harvard
- Jack Lee
- Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King’s College London
- Samantha J. Riesenfeld
- Klarman Cell Observatory, Broad Institute of MIT and Harvard
- Matan Hofree
- Klarman Cell Observatory, Broad Institute of MIT and Harvard
- Maria Aggelakopoulou
- Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- Ayshwarya Subramanian
- Klarman Cell Observatory, Broad Institute of MIT and Harvard
- Subita Balaram Kuttikkatte
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- Kathrine E. Attfield
- Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- Christiane A. E. Desel
- Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- Jessica L. Davies
- Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- Hayley G. Evans
- Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- Inbal Avraham-Davidi
- Klarman Cell Observatory, Broad Institute of MIT and Harvard
- Lan T. Nguyen
- Klarman Cell Observatory, Broad Institute of MIT and Harvard
- Danielle A. Dionne
- Klarman Cell Observatory, Broad Institute of MIT and Harvard
- Anna E. Neumann
- Broad Institute of MIT and Harvard
- Lise Torp Jensen
- Department of Clinical Medicine, Aarhus University Hospital
- Thomas R. Barber
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- Elizabeth Soilleux
- Department of Pathology, Tennis Court Rd, University of Cambridge
- Mary Carrington
- Basic Science Program, Frederick National Laboratory for Cancer Research in the Laboratory of Integrative Cancer Immunology, National Cancer Institute
- Gil McVean
- Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford
- Orit Rozenblatt-Rosen
- Klarman Cell Observatory, Broad Institute of MIT and Harvard
- Aviv Regev
- Klarman Cell Observatory, Broad Institute of MIT and Harvard
- Lars Fugger
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-022-32171-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 25
Abstract
Natural Killer cells regulate foetal growth. Here the authors use a humanized transgenic mouse to demonstrate that specific HLA-C KIR2DL interactions promote changes in maternal and foetal cell transcriptomes, resulting in modifications to placental vasculature, intercellular communications and foetal growth restriction.
