Autoantibodies and SARS-CoV-2 infection: A case report

Abstract

The article describes a COVID-19 patient with several biomarkers of systemic cytokine storm (including multiple excess over the reference values of C-reactive protein, ferritin and D-dimer) and increased level of autoantibodies (aPL and anti-CCP). At the same time contrast-enhanced CT and US failed to detect pulmonary embolism or lower limb deep vein thrombosis. Three months after discharge from the hospital, a high level of antiphospholipid antibodies and D-dimer remained. The relationship between infection with SARS-CoV-2 and autoimmunity has been discussed.

Keywords

• covid-19
• autoimmune diseases
• anti-cyclic citrullinated peptide antibodies
• anti-cardiolipin antibodies
• anti-β(2)-glycoprotein antibodies