Stabilization of the silver(I) complex with 2-(4,6-di-tert-butyl-2,3-dihydroxyphenylsulfanyl) acetic acid in the antimicrobial dosage form

Abstract

The influence of physico-chemical factors on the stability of the silver(I) complex with 2-(4,6-di-tert-butyl-2,3-dihydroxyphenylsulfanyl)acetic acid in the ointment composition based on methylcellulose hydrogel has been studied. The substance is shown to be stable provided the following conditions are fulfilled: 1) propylene glycol is used as a solvent; 2) citric acid is introduced into the ointment base of (down to pH = 4 –5) and polyvinylpyrrolidone (PVP) is added at a concentration of 5 %. The samples of ointments stable in storage are prepared, their antimicrobial activity exceeding that of «Dermazin» cream used in medical practice.

Keywords

• silver(i) complex
• hydrogel
• methylcellulose
• antimicrobial activity