CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells

Abstract

T cell bystander activation is induced by systemic inflammation. Here the authors show, using mouse model systems and correlating with human vaccination data, that localized inflammation elicits bystander activation, and that CXCR3 specifically recruits memory CD8+ T cells to sites of activated antigen-presenting cells for bystander activation.