Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape

Jonathan Sulc; Anthony Sonrel; Ninon Mounier; Chiara Auwerx; Eirini Marouli; Liza Darrous; Bogdan Draganski; Tuomas O. Kilpeläinen; Peter Joshi; Ruth J. F. Loos; Zoltán Kutalik

doi:10.1038/s42003-021-02550-y

Communications Biology (Sep 2021)

Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape

Jonathan Sulc,
Anthony Sonrel,
Ninon Mounier,
Chiara Auwerx,
Eirini Marouli,
Liza Darrous,
Bogdan Draganski,
Tuomas O. Kilpeläinen,
Peter Joshi,
Ruth J. F. Loos,
Zoltán Kutalik

Affiliations

Jonathan Sulc: University Center for Primary Care and Public Health, University of Lausanne
Anthony Sonrel: Swiss Institute of Bioinformatics
Ninon Mounier: University Center for Primary Care and Public Health, University of Lausanne
Chiara Auwerx: University Center for Primary Care and Public Health, University of Lausanne
Eirini Marouli: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry
Liza Darrous: University Center for Primary Care and Public Health, University of Lausanne
Bogdan Draganski: Laboratory for Research in Neuroimaging, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne
Tuomas O. Kilpeläinen: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Peter Joshi: Centre for Global Health Research, Usher Institute, University of Edinburgh
Ruth J. F. Loos: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
Zoltán Kutalik: University Center for Primary Care and Public Health, University of Lausanne

DOI: https://doi.org/10.1038/s42003-021-02550-y
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

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Jonathan Sulc et al. use principal component analysis and Mendelian randomization to conduct a comprehensive analysis of 14 body morphology metrics using data from the UK Biobank. Their results suggest that body size and adiposity have distinct impacts on obesity-related outcomes and highlight a BMI-neutral component affecting body fat distribution, providing further insight into the genetic basis of body shape and its consequences on human health and lifestyle.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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