Nature Communications (May 2018)
Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact
- Nadav Shai,
- Eden Yifrach,
- Carlo W. T. van Roermund,
- Nir Cohen,
- Chen Bibi,
- Lodewijk IJlst,
- Laetitia Cavellini,
- Julie Meurisse,
- Ramona Schuster,
- Lior Zada,
- Muriel C. Mari,
- Fulvio M. Reggiori,
- Adam L. Hughes,
- Mafalda Escobar-Henriques,
- Mickael M. Cohen,
- Hans R. Waterham,
- Ronald J. A. Wanders,
- Maya Schuldiner,
- Einat Zalckvar
Affiliations
- Nadav Shai
- Department of Molecular Genetics, Weizmann Institute of Science
- Eden Yifrach
- Department of Molecular Genetics, Weizmann Institute of Science
- Carlo W. T. van Roermund
- Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam
- Nir Cohen
- Department of Molecular Genetics, Weizmann Institute of Science
- Chen Bibi
- Department of Molecular Genetics, Weizmann Institute of Science
- Lodewijk IJlst
- Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam
- Laetitia Cavellini
- Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes, Institut de Biologie Physico-Chimique, Sorbonne Universités
- Julie Meurisse
- Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes, Institut de Biologie Physico-Chimique, Sorbonne Universités
- Ramona Schuster
- Institute for Genetics, CECAD Research Center, University of Cologne
- Lior Zada
- Department of Molecular Genetics, Weizmann Institute of Science
- Muriel C. Mari
- Department of Cell Biology, University of Groningen, University Medical Center Groningen
- Fulvio M. Reggiori
- Department of Cell Biology, University of Groningen, University Medical Center Groningen
- Adam L. Hughes
- Department of Biochemistry, University of Utah School of Medicine
- Mafalda Escobar-Henriques
- Institute for Genetics, CECAD Research Center, University of Cologne
- Mickael M. Cohen
- Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes, Institut de Biologie Physico-Chimique, Sorbonne Universités
- Hans R. Waterham
- Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam
- Ronald J. A. Wanders
- Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam
- Maya Schuldiner
- Department of Molecular Genetics, Weizmann Institute of Science
- Einat Zalckvar
- Department of Molecular Genetics, Weizmann Institute of Science
- DOI
- https://doi.org/10.1038/s41467-018-03957-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
The internal organization of the cell has been enriched by the discovery that organelles establish membrane contact sites, however the entire repertoire of these contacts is still being explored. Here the authors systematically identify the landscape of cellular contact sites in yeast, discovering four potential novel contact sites and two tether proteins for the peroxisome-mitochondria contact site.
