Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory

Mariana R. Matos; Esther Visser; Ioannis Kramvis; Rolinka J. van der Loo; Titia Gebuis; Robbert Zalm; Priyanka Rao-Ruiz; Huibert D. Mansvelder; August B. Smit; Michel C. van den Oever

doi:10.1038/s41467-019-10266-1

Nature Communications (May 2019)

Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory

Mariana R. Matos,
Esther Visser,
Ioannis Kramvis,
Rolinka J. van der Loo,
Titia Gebuis,
Robbert Zalm,
Priyanka Rao-Ruiz,
Huibert D. Mansvelder,
August B. Smit,
Michel C. van den Oever

Affiliations

Mariana R. Matos: Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Esther Visser: Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Ioannis Kramvis: Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Rolinka J. van der Loo: Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Titia Gebuis: Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Robbert Zalm: Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Priyanka Rao-Ruiz: Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Huibert D. Mansvelder: Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
August B. Smit: Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Michel C. van den Oever: Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam

DOI: https://doi.org/10.1038/s41467-019-10266-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Little is known about mechanisms that regulate the involvement of cortical engram cells in remote memory. Here, authors demonstrate that memory consolidation by mPFC engram cells requires CREB-mediated transcription, with the functionality of this network hub being gated by memory strength.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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