Clinical utility of 18 Fluorodeoxyglucose (FDG)-PET/CT scans in patients with suspect ocular tuberculosis

Abstract

Systemic imaging of patients with suspect ocular tuberculosis include chest X-rays and computed tomography (CT) scans. Reports have suggested a role for 18 fluorodeoxyglucose-positron emission tomography/CT (FDG-PET/CT) scans. We report on the clinical utility of 18 FDG PET/CT in two patients. Case 1: A 38-year-old female patient presented with recurrent anterior uveitis. A 18 FDG-PET scan revealed metabolically active supraclavicular and chest lymph nodes. An aspiration cytology of the cervical lymph node revealed caseating granulomas suggestive of tuberculosis. Case 2: A 58-year-old female patient presented with recurrent anterior uveitis. A 18 FDG-PET scan revealed metabolically active lymph nodes in the neck. A biopsy of the cervical lymph node revealed epithelioid granulomas suggestive of tuberculosis. Both patients were started on standard antitubercular therapy with a subsequent marked reduction of activity. PET/CT scans may suggest the sites of safe high-yield biopsies.

Keywords

• Posterior open globe injuries
• posterior to rectus insertion
• zone III open globe injuries
• Glaucoma severity
• juvenile glaucoma
• juvenile-onset primary open angle glaucoma
• visual field defects
• Diabetic retinopathy
• renal transplant
• visual outcome
• Gujarati
• logMAR
• repeatability
• validity
• visual acuity
• Multiple sclerosis
• optic neuritis
• optical coherence tomography
• retinal nerve fi ber layer
• visual functions
• Axon diameter
• electron microscopy
• nerve fiber layer
• oligodendrocytes
• pathology
• Frequency doubling technology perimetry
• pediatric visual field testing
• standard automated perimetry
• Central corneal thickness
• glaucoma
• pachymetry
• 20G Silicone rod
• monocanalicular stent
• canalicular laceration repair
• Coat′s like response
• pigmented paravenous chorioretinal atrophy
• Retinochoroiditis radiata
• Dacryocystectomy
• oculosporidiosis
• Rhinosporidium
• Infectious scleritis
• microbial scleritis
• ocular infection
• scleritis
• Congenital ectropion
• congenital eyelid imbrication syndrome
• congenital floppy eyelid syndrome
• congenital lax upper eyelid syndrome
• down syndrome
• Inner retinal layer thickness
• optic nerve hypoplasia
• outer retinal layer thickness
• retinal nerve fiber layer thickness
• spectral domain optical coherence tomography
• Abducens nerve palsy
• hyperhomocysteinemia
• isolated abducens nerve palsy
• nontraumatic
• Inverted internal limiting membrane flap technique
• macular hole
• macular hole surgery
• Ocular
• positron emission tomography
• tuberculosis