Exceptional initial response of prostate cancer lung metastases to 225Ac-PSMA: A case report

Letjie C. Maserumule; Kgomotso M.G. Mokoala; Khanyi N. Hlongwa; Honest Ndlovu; Janet D. Reed; Aisha Ismail; Tebatso M.G. Boshomane; Ismaheel O. Lawal; Neo P. Mokgoro; Mariza Vorster; Frank Bruchertseifer; Otto Knoesen; Alfred Morgenstern; Mike M. Sathekge

Current Problems in Cancer: Case Reports (Mar 2021)

Exceptional initial response of prostate cancer lung metastases to 225Ac-PSMA: A case report

Letjie C. Maserumule,
Kgomotso M.G. Mokoala,
Khanyi N. Hlongwa,
Honest Ndlovu,
Janet D. Reed,
Aisha Ismail,
Tebatso M.G. Boshomane,
Ismaheel O. Lawal,
Neo P. Mokgoro,
Mariza Vorster,
Frank Bruchertseifer,
Otto Knoesen,
Alfred Morgenstern,
Mike M. Sathekge

Affiliations

Letjie C. Maserumule: Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa
Kgomotso M.G. Mokoala: Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa
Khanyi N. Hlongwa: Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa
Honest Ndlovu: Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa
Janet D. Reed: Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa
Aisha Ismail: Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa
Tebatso M.G. Boshomane: Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa
Ismaheel O. Lawal: Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa; Nuclear Medicine Research Infrastructure (NuMeRI), Steve Biko Academic Hospital, South Africa European Commission, Pretoria, South Africa
Neo P. Mokgoro: Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa
Mariza Vorster: Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa; Nuclear Medicine Research Infrastructure (NuMeRI), Steve Biko Academic Hospital, South Africa European Commission, Pretoria, South Africa
Frank Bruchertseifer: Joint Research Centre, Directorate for Nuclear Safety and Security, Karlsruhe, Germany
Otto Knoesen: Nuclear Technology Products (NTP), Pelindaba, South Africa
Alfred Morgenstern: Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa; Joint Research Centre, Directorate for Nuclear Safety and Security, Karlsruhe, Germany
Mike M. Sathekge: Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa; Nuclear Medicine Research Infrastructure (NuMeRI), Steve Biko Academic Hospital, South Africa European Commission, Pretoria, South Africa; Corresponding author at: Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa.

Journal volume & issue: Vol. 3
p. 100038

Abstract

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Prostate cancer is the commonest non-cutaneous cancer in males and frequently metastasizes to nodal and skeletal tissues. Metastases to soft tissue viscera such as lung and liver are associated with decreased overall survival compared to nodal and skeletal metastases despite androgen deprivation and chemotherapy with palliative intent.We present a case with complete resolution of lung metastases after 225Ac-PSMA targeted alpha endoradiotherapy in a treatment naïve patient with metastatic prostate cancer. Our case gives preliminary clinical support for the efficacy of 225Ac-PSMA therapy in lung metastases.

Published in Current Problems in Cancer: Case Reports

ISSN: 2666-6219 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.journals.elsevier.com/current-problems-in-cancer-case-reports/

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