Time in Therapeutic Range, as a Determinant of All‐Cause Mortality in Patients With Hypertension

Abstract

BackgroundAccumulating evidence indicates that reducing systolic blood pressure (BP) to 3, 1 or 2, and none, respectively). Time within, above, or below therapeutic range (120–140 mm Hg) was considered in quartiles and related to all‐cause mortality. The study population consisted of 54% hypertensive, 19.9% intermediate, and 26.1% normotensive participants; the corresponding mortality rates for the 3 groups were 11.5%, 8%, and 1.9%, respectively (P75%) to 8.9%, 15.6%, and 23.5% towards the less consistently controlled quartiles (50–75%, 25–50%, and <25%, respectively; P<0.0001 for all comparisons). ConclusionsAn inverse and gradual association between time in therapeutic range and all‐cause mortality was observed in this large veteran cohort. Consistency of BP control over time is a strong determinant of all‐cause mortality, and consistency of BP control should be monitored in everyday clinical practice.

Keywords

• hypertension
• mortality
• variation