Гинекология (Apr 2017)
Characteristic of the metabolic and nutritional status of patients with functional hypothalamic amenorrhea
Abstract
The aim of the study - to analyze the nutritional status, fat content and leptin in patients with functional hypothalamic amenorrhea (FHA). Subjects and methods. Clinical and laboratory methods were performed to examine 48 patients with FHA (age 25.8±5.43 years, BMI 19.7±2.01 kg/m2), including an assessment of the nutrient intake, eating behavior, lipid profile, leptin level and body composition by using dual-energy X-ray absorptiometry. Results. Body weight loss was observed in 29.2% of patients, body fat deficiency - in 100% of patients with low and in 58.8% with normal BMI respectively. Hypoleptinemia was detected in 77.1% of patients, hypercholesterolemia without increasin go fatherogenic index in 68.8% of patients. The analysis of the EDI-2 questionnaires showed that 54.2% of patients had drive for thinness, 22.9% of patients had body dissatisfaction. Nutritional examination showed a decrease of caloric intake in 50% of patients, daily carbohydrate intake - in 91.7%, increase protein intake in 70.8%, fats in 62.5% of patients. The ratio of nutrient consumption (proteins, fats, carbohydrates) was 1:1:0.3. Conclusion. The revealed features of the metabolic and nutritional status of patients with FHA point to the need for multidisciplinary interaction of the gynecologist, nutritionist and psychotherapist to normalize eating behavior, energy balance, total body fat percentage and menstrual status.