Dynamic FDG PET/CT for differentiating focal pelvic uptake in patients with gynecological cancer

Abstract

Abstract This study aimed to evaluate the ability of serial whole-body dynamic PET/CT to differentiate physiological from abnormal 18F-FDG uptake in the abdomen and pelvis of gynecological cancer patients. We conducted a retrospective study of 61 18F-FDG PET/CT examinations for suspected gynecological malignancies or metastases between March 2018 and January 2020. Our protocol included four-phase dynamic whole-body scans. High-uptake foci with SUVmax > 2.5 in the abdominopelvic region caudal to the renal portal were picked up and visually evaluated as “changed” (disappeared during any phase or morphological changes in more than half of the foci) or “unchanged” in motion on the serial dynamic images. Focal 18F-FDG uptake was observed in 84 foci. Of the 58 foci determined pathologically or clinically to have pathological uptake, no change was observed on serial dynamic imaging in 54 foci (sensitivity, 93%). Of the 26 foci of physiological uptake, temporal changes in uptake were observed in 20 foci using dynamic imaging (specificity, 77%). The positive and negative predictive values were 90% and 83%, respectively, with an accuracy of 88%. Dynamic whole-body 18F-FDG PET/CT imaging allows for differentiation between pathological and physiological uptake in the abdominopelvic region of patients with gynecological cancer.

Keywords

• Whole-body PET/CT
• 18F-FDG
• Dynamic acquisition
• Gynecological cancer
• Physiological uptake