Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice

Aniruddha Adhikari; Susmita Mondal; Tanima Chatterjee; Monojit Das; Pritam Biswas; Ria Ghosh; Soumendra Darbar; Hussain Alessa; Jalal T. Althakafy; Ali Sayqal; Saleh A. Ahmed; Anjan Kumar Das; Maitree Bhattacharyya; Samir Kumar Pal

doi:10.1038/s42003-021-02546-8

Communications Biology (Aug 2021)

Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice

Aniruddha Adhikari,
Susmita Mondal,
Tanima Chatterjee,
Monojit Das,
Pritam Biswas,
Ria Ghosh,
Soumendra Darbar,
Hussain Alessa,
Jalal T. Althakafy,
Ali Sayqal,
Saleh A. Ahmed,
Anjan Kumar Das,
Maitree Bhattacharyya,
Samir Kumar Pal

Affiliations

Aniruddha Adhikari: Department of Chemical, Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences
Susmita Mondal: Department of Chemical, Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences
Tanima Chatterjee: Department of Biochemistry, University of Calcutta
Monojit Das: Department of Zoology, Uluberia College, University of Calcutta, Uluberia
Pritam Biswas: Department of Microbiology, St. Xavier’s College
Ria Ghosh: Department of Biochemistry, University of Calcutta
Soumendra Darbar: Research & Development Division, Dey’s Medical Stores (Mfg.) Ltd
Hussain Alessa: Department of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University
Jalal T. Althakafy: Department of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University
Ali Sayqal: Department of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University
Saleh A. Ahmed: Department of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University
Anjan Kumar Das: Department of Pathology, Calcutta National Medical College and Hospital
Maitree Bhattacharyya: Department of Biochemistry, University of Calcutta
Samir Kumar Pal: Department of Chemical, Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences

DOI: https://doi.org/10.1038/s42003-021-02546-8
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 15

Abstract

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Adhikari et al. use the redox modulatory abilities of citrate functionalized Mn3O4 nanoparticles to ameliorate oxidative damage in murine disease model of chronic kidney disease (CKD). This nanomedicine works by protecting structural and functional integrity of mitochondria from oxidative injury, reducing intracellular ROS, downregulating pro-inflammatory cytokines and maintaining cellular redox homeostasis.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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