Spatial transcriptomics analysis of zone-dependent hepatic ischemia-reperfusion injury murine model

Jiaqi Xin; Ting Yang; Xiaoyi Wu; Yingting Wu; Yi Liu; Xuan Liu; Mengxi Jiang; Wei Gao

doi:10.1038/s42003-023-04564-0

Communications Biology (Feb 2023)

Spatial transcriptomics analysis of zone-dependent hepatic ischemia-reperfusion injury murine model

Jiaqi Xin,
Ting Yang,
Xiaoyi Wu,
Yingting Wu,
Yi Liu,
Xuan Liu,
Mengxi Jiang,
Wei Gao

Affiliations

Jiaqi Xin: School of Traditional Chinese Medicine, Capital Medical University
Ting Yang: Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University
Xiaoyi Wu: School of Traditional Chinese Medicine, Capital Medical University
Yingting Wu: Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University
Yi Liu: Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University
Xuan Liu: School of Traditional Chinese Medicine, Capital Medical University
Mengxi Jiang: Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University
Wei Gao: School of Traditional Chinese Medicine, Capital Medical University

DOI: https://doi.org/10.1038/s42003-023-04564-0
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 13

Abstract

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Liver zonation across a murine ischemia/reperfusion injury model is characterised and the protective effect of celastrol against I/R injury by activating HIF1α signaling is presented, representing a novel strategy for resolving liver I/R

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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