Nature Communications (Jan 2023)

Gut colonisation with multidrug-resistant Klebsiella pneumoniae worsens Pseudomonas aeruginosa lung infection

  • Rémi Le Guern,
  • Teddy Grandjean,
  • Sarah Stabler,
  • Marvin Bauduin,
  • Philippe Gosset,
  • Éric Kipnis,
  • Rodrigue Dessein

DOI
https://doi.org/10.1038/s41467-022-35767-4
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 12

Abstract

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Gut microbiome dysbiosis has been shown to alter the immune response to lung infection. Authors utilise a murine model to investigate if gut colonisation with carbapenemase-producing Enterobacterales altered the outcomes of Pseudomonas aeruginosa lung infection.