CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment

Tao Zhang; Chieh Tseng; Yan Zhang; Olga Sirin; Paul G. Corn; Elsa M. Li-Ning-Tapia; Patricia Troncoso; John Davis; Curtis Pettaway; John Ward; Marsha L. Frazier; Christopher Logothetis; Mikhail G. Kolonin

doi:10.1038/ncomms11674

Nature Communications (May 2016)

CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment

Tao Zhang,
Chieh Tseng,
Yan Zhang,
Olga Sirin,
Paul G. Corn,
Elsa M. Li-Ning-Tapia,
Patricia Troncoso,
John Davis,
Curtis Pettaway,
John Ward,
Marsha L. Frazier,
Christopher Logothetis,
Mikhail G. Kolonin

Affiliations

Tao Zhang: The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
Chieh Tseng: The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
Yan Zhang: The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
Olga Sirin: The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
Paul G. Corn: Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center
Elsa M. Li-Ning-Tapia: Department of Pathology, The University of Texas MD Anderson Cancer Center
Patricia Troncoso: Department of Pathology, The University of Texas MD Anderson Cancer Center
John Davis: Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center
Curtis Pettaway: Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center
John Ward: Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center
Marsha L. Frazier: Department of Epidemiology, The University of Texas MD Anderson Cancer Center
Christopher Logothetis: Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center
Mikhail G. Kolonin: The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston

DOI: https://doi.org/10.1038/ncomms11674
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 16

Abstract

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Adipose stromal cells (ASC) have been shown to migrate to tumours and promote tumour growth. Using animal models and human tissue samples, the authors show here that ASC recruitment to prostate cancers is mediated by the chemokine CXCL1, which is secreted from tumour cells, and acts on CXCR1 on ASCs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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