Molecular Epidemiology of Group A <em>Streptococcus</em> Infections in The Gambia

Sona Jabang; Annette Erhart; Saffiatou Darboe; Aru-Kumba Baldeh; Valerie Delforge; Gabriella Watson; Ebenezer Foster-Nyarko; Rasheed Salaudeen; Bolarinde Lawal; Grant Mackenzie; Anne Botteaux; Martin Antonio; Pierre R. Smeesters; on behalf of The MRCG StrepA Study Group

doi:10.3390/vaccines9020124

Vaccines (Feb 2021)

Molecular Epidemiology of Group A <em>Streptococcus</em> Infections in The Gambia

Sona Jabang,
Annette Erhart,
Saffiatou Darboe,
Aru-Kumba Baldeh,
Valerie Delforge,
Gabriella Watson,
Ebenezer Foster-Nyarko,
Rasheed Salaudeen,
Bolarinde Lawal,
Grant Mackenzie,
Anne Botteaux,
Martin Antonio,
Pierre R. Smeesters,
on behalf of The MRCG StrepA Study Group

Affiliations

Sona Jabang: Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The Gambia
Annette Erhart: Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The Gambia
Saffiatou Darboe: Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The Gambia
Aru-Kumba Baldeh: Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The Gambia
Valerie Delforge: Laboratoire de Génétique et Physiologie Bactérienne, IBMM, Université Libre de Bruxelles, 12 Rue des Professeurs Jenner et Brachet, 6041 Gosselies, Belgium
Gabriella Watson: Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The Gambia
Ebenezer Foster-Nyarko: Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The Gambia
Rasheed Salaudeen: Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The Gambia
Bolarinde Lawal: Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The Gambia
Grant Mackenzie: Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The Gambia
Anne Botteaux: Laboratoire de Génétique et Physiologie Bactérienne, IBMM, Université Libre de Bruxelles, 12 Rue des Professeurs Jenner et Brachet, 6041 Gosselies, Belgium
Martin Antonio: Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The Gambia
Pierre R. Smeesters: Laboratoire de Génétique et Physiologie Bactérienne, IBMM, Université Libre de Bruxelles, 12 Rue des Professeurs Jenner et Brachet, 6041 Gosselies, Belgium
on behalf of The MRCG StrepA Study Group

DOI: https://doi.org/10.3390/vaccines9020124
Journal volume & issue: Vol. 9, no. 2
p. 124

Abstract

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Molecular epidemiological data on Group A Streptococcus (GAS) infection in Africa is scarce. We characterized the emm-types and emm-clusters of 433 stored clinical GAS isolates from The Gambia collected between 2004 and 2018. To reduce the potential for strain mistyping, we used a newly published primer for emm-typing. There was considerable strain diversity, highlighting the need for vaccine development offering broad strain protection.

Published in Vaccines

ISSN: 2076-393X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/vaccines

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