MORPHOLOGICAL CHANGES IN HEMOCIRCULATORY BED OF GUINEA PIG TRACHEA AT EXPERIMENTAL OVALBUMIN-INDUCED ALLERGIC IGNITION

Abstract

. To date, the blood vessels in allergic diseases of the respiratory system are an acting problem. It is known that the full functioning of tissues and organs depends on the state of vessels of a hemomicrocirculatory bed. The purpose of the work is to study morphological changes in the vessels of the hemomicrocirculatory channel of the guinea pig trachea with experimental ovalbumin-induced allergic inflammation. Material and methods. With the help of histological, morphometric and statistical methods studied the trachea of 48 male guinea pigs in conditions of experimental ovalbumin-induced allergic inflammation, which was modeled by subcutaneous sensitization and the subsequent inhalation of ovalbumin. To determine the structural and functional adjustment of arterioles, venules and blood capillaries, the outer diameter, diameter of the lumen, the thickness of the middle membrane and the cereal index of arterioles, the diameter of the lumen of venules and capillaries were determined. The results. It has been found that in all study groups, the size of the outer diameter of arterioles is increased (P */** <0.05), the maximum index is installed in the 3rd group, an increase of 2 times compared to the control group. Growth of the diameter of the lumen (P */** <0.05) found in all groups of research, maximum growth of 1.4 times installed on 36th day of the experiment (3rd group). Statistical enlargement (P */** <0.05) The middle membrane of the arteriol is detected in all experimental groups, increased increased in the late experiment. Growth of the index of the kernoghan index in 1st, 2nd, 3rd and 4th experimental groups (respectively 1.7; 2; 1.7 and 1.9 times) compared to the analogous control group (P */** <0.05). Increasing the diameter of the lumen of muscle venules was observed in all experimental groups, the maximum indicators were observed in the late experiment period. The most significant changes in the diameter of the lumen of blood capillaries of the trachea are almost 1.5 times less than a similar indicator of the control group recorded in the 4th group of research.

Keywords

• arteriol
• venal
• capillary
• trachea
• experimental allergic inflammation
• ovalbumin
• guinea pig.