Frontiers in Human Neuroscience (Aug 2020)

Association Between Interictal High-Frequency Oscillations and Slow Wave in Refractory Focal Epilepsy With Good Surgical Outcome

  • Guoping Ren,
  • Guoping Ren,
  • Jiaqing Yan,
  • Yueqian Sun,
  • Yueqian Sun,
  • Yueqian Sun,
  • Jiechuan Ren,
  • Jiechuan Ren,
  • Jindong Dai,
  • Shanshan Mei,
  • Yunlin Li,
  • Xiaofei Wang,
  • Xiaofeng Yang,
  • Xiaofeng Yang,
  • Xiaofeng Yang,
  • Qun Wang,
  • Qun Wang,
  • Qun Wang

DOI
https://doi.org/10.3389/fnhum.2020.00335
Journal volume & issue
Vol. 14

Abstract

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High-frequency oscillations (HFOs) have been proposed as a promising biomarker of the epileptogenic zone (EZ). But accurate delineation of EZ based on HFOs is still challenging. Our study compared HFOs from EZ and non-EZ on the basis of their associations with interictal slow waves, aiming at exploring a new way to localize EZ. Nineteen medically intractable epilepsy patients with good surgical outcome were included. Five minute interictal intracranial electroencephalography (EEG) epochs of slow-wave sleep were randomly selected; then ripples (80–200 Hz), fast ripples (FRs; 200–500 Hz), and slow waves (0.1–4 Hz) were automatically analyzed. The EZ and non-EZ were identified by resection range during the surgeries. We found that both ripples and FRs superimposed more frequently on slow waves in EZ than in non-EZ (P < 0.01). Although ripples preferred to occur on the down state of slow waves in both two groups, ripples in EZ tended to be closer to the down-state peak of slow wave than in non-EZ (-174 vs. -231 ms, P = 0.008). As for FR, no statistical difference was found between the two groups (P = 0.430). Additionally, slow wave-containing ripples in EZ had a steeper slope (1.7 vs. 1.5 μV/ms, P < 0.001) and wider distribution ratio (32.3 vs. 30.1%, P < 0.001) than those in the non-EZ. But for slow wave-containing FR, only a steeper slope (1.7 vs. 1.4 μV/ms, P < 0.001) was observed. Our study innovatively compared the different features of association between HFOs and slow wave in EZ and non-EZ from refractory focal epilepsy with good surgical outcome, proposing a new method to localize EZ and facilitating the surgical plan.

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