Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species

Kate S. Baker; Timothy J. Dallman; Nigel Field; Tristan Childs; Holly Mitchell; Martin Day; François-Xavier Weill; Sophie Lefèvre; Mathieu Tourdjman; Gwenda Hughes; Claire Jenkins; Nicholas Thomson

doi:10.1038/s41467-018-03949-8

Nature Communications (Apr 2018)

Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species

Kate S. Baker,
Timothy J. Dallman,
Nigel Field,
Tristan Childs,
Holly Mitchell,
Martin Day,
François-Xavier Weill,
Sophie Lefèvre,
Mathieu Tourdjman,
Gwenda Hughes,
Claire Jenkins,
Nicholas Thomson

Affiliations

Kate S. Baker: Institute for Integrative Biology, University of Liverpool
Timothy J. Dallman: Gastrointestinal Bacterial Reference Unit, National Infection Service, Public Health England
Nigel Field: Centre for Molecular Epidemiology and Translational Research, Institute for Global Health, UCL
Tristan Childs: Centre for Infectious Disease Surveillance and Control, National Infection Service, Public Health England
Holly Mitchell: Centre for Molecular Epidemiology and Translational Research, Institute for Global Health, UCL
Martin Day: Gastrointestinal Bacterial Reference Unit, National Infection Service, Public Health England
François-Xavier Weill: Institut Pasteur, Unité des Bactéries Pathogènes Entériques
Sophie Lefèvre: Institut Pasteur, Unité des Bactéries Pathogènes Entériques
Mathieu Tourdjman: Santé Publique France, the French Public Health Agency
Gwenda Hughes: Department of HIV and STIs, National Infection Service, Public Health England
Claire Jenkins: Gastrointestinal Bacterial Reference Unit, National Infection Service, Public Health England
Nicholas Thomson: Wellcome Trust Sanger Institute

DOI: https://doi.org/10.1038/s41467-018-03949-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

Read online

Antimicrobial resistance (AMR) in Shigella species is a public health concern. Here, Baker et al. show how horizontal transfer of an AMR plasmid among Shigella species contributes to epidemics in men who have sex with men in England.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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